Digoxin acts as a positive inotrope and what else?

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Multiple Choice

Digoxin acts as a positive inotrope and what else?

Explanation:
Digoxin provides a stronger heart squeeze by increasing intracellular calcium in cardiac myocytes, which is a positive inotropic effect. At the same time, it enhances vagal (parasympathetic) tone, which slows the heart rate and reduces AV nodal conduction—this is a negative chronotropic effect. So, besides being a positive inotrope, it acts to decrease heart rate. It is not a diuretic or a vasodilator, and it does not increase heart rate.

Digoxin provides a stronger heart squeeze by increasing intracellular calcium in cardiac myocytes, which is a positive inotropic effect. At the same time, it enhances vagal (parasympathetic) tone, which slows the heart rate and reduces AV nodal conduction—this is a negative chronotropic effect. So, besides being a positive inotrope, it acts to decrease heart rate. It is not a diuretic or a vasodilator, and it does not increase heart rate.

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